Chemistry Capabilities
· Organometallic reactions
· Oxidation reductions
· Hydrogenation reactions
· Asymmetric synthesis
· Alkylations
· Brominations / Fluorinations
· Homogeneous catalytic reductions
· Processsafety assessment: Fully automatic reaction calorimeter (RC), differentialscanning calorimeter (DSC), etc.
· Enzyme-catalyzed resolutions
· Design of Experiment（DoE） and parallel synthesis
Process Development Capabilities
Regarding process development of active pharmaceutical ingredients, the R&D department of SciAnda (Changshu) Pharmaceuticals, Ltd. has already applied/is applying for more than 12 patents
· Nucleotide-drug process development.At present, a variety of nucleotide/derivative syntheses have been completed(all have analytical samples)
· Prostaglandin platform technology:Currently, the synthetic pathways of two prostaglandins have beendeveloped
· Enzymatic decomposition of racemicalcohols
· Barbier reaction (organic zincchemistry)
· Copper acid chemistry (1,4-conjugateaddition)
· Palladium-coupling chemistry (Suzukiand Hartwig-Buchwald coupling)
· Asymmetric synthesis catalyzed byreactions such as the Sharpless dihydroxylation reaction and Trost allylationreaction
Analytical Capabilities
The analytical R&D department of SciAnda (Changshu) Pharmaceuticals, Ltd. has experienced analysts and complete analytical equipment, can provide various analytical services needed for supporting process research and drug application, including analytical methods development, validation, transfer, as well as characterization of physical and chemical properties analysis and spectral analysis/structural identification.
